Kunskapsstöd, forskning och utveckling (FoUUI)

Lokala, regionala, nationella och internationella kunskapsstöd som expertteamet använder sig av samt vetenskapliga publikationer av expertteamet.

Vilka är relevanta? Finns fler: lokala/regionala/nationella/internationella? (länkarna kommer snyggast till när vi vet vilka som är aktuella)

Regionala kunskapsstöd

  •  

Nationella kunskapsstöd

Internationella kunskapsstöd

Vetenskapliga publikationer av teamet

Andersson, N. G., Brange, H., Astermark, J., Axelsson, M., Baghaei, F., Magnusson, M., Olsson, A., Olsson, E., Ranta, S., Myrin Westesson, L., & Holmström, M. (2024). Low bleeding rates after intramuscular Covid‐19 vaccination in patients with haemophilia and von Willebrand disease: Outcome data from the Swedish haemophilia registry. Haemophilia : the Official Journal of the World Federation of Hemophilia. https://doi.org/10.1111/hae.15063 

Mulders, G., Uitslager, N., Kavanagh, M., Birkedal, M. F., Nicolo, G., Fenton, R., & Myrin Westesson, L. (2024). The role of the specialist nurse in comprehensive care for bleeding disorders in Europe: An integrative review. Haemophilia : the Official Journal of the World Federation of Hemophilia, 30(3), 598–608. https://doi.org/10.1111/hae.14974 

Arvanitakis, A., Jepsen, C., Andersson, N. G., Baghaei, F., & Astermark, J. (2024). Primary prophylaxis implementation and long-term joint outcomes in Swedish haemophilia A patients. Haemophilia : the Official Journal of the World Federation of Hemophilia, 30(3), 671–677. https://doi.org/10.1111/hae.15013 

Boban, A., Baghaei, F., Karin, F., Klamroth, R., Miesbach, W., Stephensen, D., Kavanagh, M., Noone, D., Crato, M., & Peyvandi, F. (2023). Accreditation model of European Haemophilia Centres in the era of novel treatments and gene therapy. Haemophilia : the Official Journal of the World Federation of Hemophilia, 29(6), 1442–1449. https://doi.org/10.1111/hae.14887 

Steen Carlsson K, Winding B, Astermark J, et al. High use of pain, depression, and anxiety drugs in hemophilia: more than 3000 people with hemophilia in an 11-year Nordic registry study. Res Pract Thromb Haemost. 2023;7(2):100061. doi:10.1016/j.rpth.2023.100061

Lindahl R, Nummi V, Lehtinen AE, et al. Acquired Haemophilia A in four north European countries: survey of 181 patients. Br J Haematol. 2023;201(2):326-333. doi:10.1111/bjh.18611

Kihlberg K, Baghaei F, Bruzelius M, et al. No difference in quality of life between persons with severe haemophilia A and B. Haemophilia. 2023;29(4):987-996. doi:10.1111/hae.14759

Olsson A, Petrini P, Engman Grahn E, Myrin Westesson L. HRQoL and psychosocial aspects of burden on caregivers to children with moderate or severe von Willebrand disease. Haemophilia. 2023;29(4):1056-1062. doi:10.1111/hae.14811

Lundin B, Baghaei F, Holmström M, et al. Haemophilia A and B - evaluation of the Swedish prophylactic regimen by magnetic resonance imaging. Haemophilia. 2023;29(1):193-198. doi:10.1111/hae.14693

Olsson A, Myrin Westesson L, Baghaei F, et al. Real-world prophylactic usage of recombinant factor IX Fc in Sweden: A report from the Swedish National Registry for bleeding disorders. Haemophilia. 2023;29(1):377-381. doi:10.1111/hae.14704

Myrin Westesson L, Petrini P, Grahn EE, Olsson A. Burden on parents of children with moderate or severe von Willebrand disease: The impact of clinical data. Haemophilia. 2023;29(1):390-393. doi:10.1111/hae.14718

Miesbach W, Baghaei F, Boban A, et al. Gene therapy of hemophilia: Hub centres should be haemophilia centres: A joint publication of EAHAD and EHC. Haemophilia. 2022;28(3). doi:10.1111/hae.14546

Lehtinen AE, Baghaei F, Astermark J, Holme PA. Surgical outcomes in patients with haemophilia A or B receiving extended half-life recombinant factor VIII and IX Fc fusion proteins: Real-world experience in the Nordic countries. Haemophilia. 2022;28(5):713-719. doi:10.1111/hae.14585

Khair K, Klukowska A, Myrin Westesson L, et al. The burden of bleeds and other clinical determinants on caregivers of children with haemophilia (the BBC Study). Haemophilia. 2019;25(3):416-423. doi:10.1111/hae.13736

von Mackensen S, Myrin Westesson L, Kavakli K, et al. The impact of psychosocial determinants on caregivers’ burden of children with haemophilia (results of the BBC study). Haemophilia. 2019;25(3):424-432. doi:10.1111/hae.13684

Kihlberg K, Baghaei F, Bruzelius M, et al. Treatment outcomes in persons with severe haemophilia B in the Nordic region: The B-NORD study. Haemophilia. 2021;27(3):366-374. doi:10.1111/hae.14299

Måseide RJ, Berntorp E, Astermark J, et al. Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study. Haemophilia. 2021;27(2). doi:10.1111/hae.14245

Astermark J, Olsson A, Chelle P, et al. Comparison of single subject and population-based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A. Haemophilia. 2021;27(4):626-633. doi:10.1111/hae.14329

Holmström M, Olsson E, Astermark J, et al. Real-world prophylactic usage of recombinant factor VIII Fc in Sweden: A report from the Swedish national registry for bleeding disorders. Haemophilia. 2021;27(4). doi:10.1111/hae.14316

Letelier A, Ljung R, Olsson A, Andersson NG. Silent variant in F8.222G>T (p.Thr74Thr) causes a partial exon skipping in a patient with mild hemophilia A. Mol Genet Genomic Med. 2022;10(1) doi:10.1002/mgg3.1856

Kihlberg K, Baghaei F, Bruzelius M, et al. Factor IX antibodies and tolerance in hemophilia B in the Nordic countries - The impact of F9 variants and complications. Thromb Res. 2022;217:22-32. doi:10.1016/j.thromres.2022.06.015

Steen Carlsson K, Winding B, Astermark J, et al. Pain, depression and anxiety in people with haemophilia from three Nordic countries: Cross-sectional survey data from the MIND study. Haemophilia. 2022;28(4):557-567. doi:10.1111/hae.14571

Szanto T, Zetterberg E, Ramström S, et al. Platelet function testing: Current practice among clinical centres in Northern Europe. Haemophilia. 2022;28(4):642-648. doi:10.1111/hae.14578

Måseide RJ, Berntorp E, Astermark J, et al. Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study. Haemophilia. 2020;26(5):891-897. doi:10.1111/hae.14114

Olsson A, Radulovic V, Wennerholm UB. Maternal and neonatal outcomes in carriers of haemophilia A and B: A Swedish Medical Birth Register study. Haemophilia. 2020;26(1). doi:10.1111/hae.13884

Lövdahl S, Henriksson KM, Baghaei F, Holmström M, Berntorp E, Astermark J. Hypertension and cardiovascular diseases in Swedish persons with haemophilia - A longitudinal registry study. Thromb Res. 2019;181:106-111. doi:10.1016/j.thromres.2019.07.017

Khair K, Klukowska A, Myrin Westesson L, et al. The burden of bleeds and other clinical determinants on caregivers of children with haemophilia (the BBC Study). Haemophilia. 2019;25(3):416-423. doi:10.1111/hae.13736

Osooli M, Lövdahl S, Steen Carlsson K, et al. Comparative burden of arthropathy in mild haemophilia: a register-based study in Sweden. Haemophilia. 2017;23(2). doi:10.1111/hae.13166

Osooli M, Steen Carlsson K, Baghaei F, et al. The association between health utility and joint status among people with severe haemophilia A: findings from the KAPPA register. Haemophilia. 2017;23(3). doi:10.1111/hae.13231

Negrier C, Voisin S, Baghaei F, et al. Global Post-Authorization Safety Surveillance Study: real-world data on prophylaxis and on-demand treatment using FEIBA (an activated prothrombin complex concentrate). Blood Coagul Fibrinolysis. 2016;27(5):551-556. doi:10.1097/MBC.0000000000000525

Salim M, Brodin E, Spaals-Abrahamsson Y, Berntorp E, Zetterberg E. The effect of Nordic Walking on joint status, quality of life, physical ability, exercise capacity and pain in adult persons with haemophilia. Blood Coagul Fibrinolysis. 2016;27(4):467-472. doi:10.1097/MBC.0000000000000554

Consensus report on markers to distinguish procoagulant platelets from apoptotic platelets: communication from the Scientific and Standardization Committee of the ISTH.
Josefsson EC, Ramström S, Thaler J, Lordkipanidzé M; COAGAPO study group.J Thromb Haemost. 2023 Aug;21(8):2291-2299. doi: 10.1016/j.jtha.2023.05.001. Epub 2023 May 10.PMID: 37172731

Au AE, Corbin JE, Lebois M, Gangatirkar P, Yassinson F, Hyslop SR, Cannon P, Mason KD, Lo-Wai-Suen CS, Garnham AL, Moujalled D, Cimmino L, Alexander WS, Josefsson EC. Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels. Blood Adv. 2023 Apr 25;7(8):1560-1571. doi: 10.1182/bloodadvances.2022007849.PMID: 36075025 

Hearn JI, Green TN, Hisey CL, Bender M, JOSEFSSON EC, Knowlton N, Baumann J, Bohlander SK, Kalev-Zylinska ML. Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation Blood. 2022 Apr 28;139(17):2673-2690. Doi: 10.1182/blood.2021014000. PMID: 35245376

Heazlewood S, Ahmad T, Mohenska M, Guo BB, Gangatirkar P, JOSEFSSON EC, Ellis S, Ratnadiwakara M, Cao H, Cao B, Heazlewood C, Williams B, Fulton M, White J, Ramialison M, Nilsson SK, Anko ML. RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production. Blood. 2022 Mar 3;139(9):1359-1373. doi: 10.1182/blood.2021013826. PMID: 34852174.

Moujalled D, Gangatirkar P, Kauppi M, Corbin.  J, Lebois M, Murphy JM, Lalaoui N, Hildebrand JM, Silke J, Alexander WS, JOSEFSSON EC. The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis. Cell Death Dis. 2021 Jan 28;12(1):133. doi: 10.1038/s41419-021-03418-z.PMID: 33510145

Lee MKS, Kraakman MJ, Dragoljevic D, Hanssen NMJ, Flynn MC, Al-Sharea A, Sreejit G, Bertuzzo-Veiga C, Cooney OD, Baig F, Morriss E, Cooper ME, JOSEFSSON EC, Kile BT, Nagareddy PR, Murphy AJ. Apoptotic ablation of platelets reduces atherosclerosis in mice with diabetes. Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1167-1178. doi: 10.1161/ATVBAHA.120.315369. PMID: 33441028

Potts K, Farley A, Dawson CA, Rimes J, Biben C, de Graaf C, Potts MA, Stonehouse OJ, Carmagnac A, Gangatirkar P, JOSEFSSON EC, Anttila C, Zalcenstein D, Naik S, Alexander WS, Hilton DJ, Hawkins E, and Taoudi S. Membrane budding is a major mechanism of in vivo platelet biogenesis. Journal of Experimental Medicine. 2020 Sep 7;217(9):e20191206. doi: 10.1084/jem.20191206. PMID: 32706855

Hyslop SR, Alexander M, Thai A, Kersbergen A, Kueh A, Herold M, Corbin J, Gangatirkar P, Ng AP, Solomon B, Alexander WS, Sutherland K, JOSEFSSON EC. Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma. Oncogene. 2020 Jul;39(29):5177-5186. doi: 10.1038/s41388-020-1357-6. PMID: 32535617

Martini C, Thompson EJ, Hyslop SR, Cockshell MP, Dale BJ, Ebert LM, Woods AE, JOSEFSSON EC, Bonder CS. Platelets disrupt vasculogenic mimicry by cancer cells. Sci Rep. 2020 Apr 3;10(1):5869. doi: 10.1038/s41598-020-62648-x.PMID: 32246008 

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, #Kile BT, #JOSEFSSON EC. Intrinsic apoptosis circumvents the functional decline of circulating platelets, but does not cause the storage lesion. Blood. 2018 Jul 12;132(2):197-209 PMID:29784641.

Kamal T, Green TN, Hearn JI, JOSEFSSON EC, Morel-Kopp M, Ward CM, During, Kalev-Zylinska ML N-methyl-d-aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines. Research and Practice in Thrombosis and Haemostasis 2017 Dec 14;2(1):125-138. PMID:30046713

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, JOSEFSSON EC, Kile BT, Jackson SP. Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci Transl Med. 2017 Sep 27;9(409). PMID:28954929.

Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, JOSEFSSON EC. Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. J Thromb Haemost. 2016 Sep;14(9):1882-7. doi:10.1111/jth.13397. PMID:27344013.

Potts KS, Sargeant TJ, Dawson C, JOSEFSSON EC, Hilton DJ, Alexander WS, Taoudi S. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood 2015 Aug 6;126(6):807-16. PMID: 25995324

Kamal T, Green TN, Morrel-Kopp MC, Ward CM, McGregor AL, McGlashan SR, Bohlander SK, Browett PJ, Teague L, Skerry TM, JOSEFSSON EC, Kalev-Zylinska ML. Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation. Cellular Signalling 2015 Sep;27(9):1860-72. PMID: 25982509

Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, #Kile BT, #JOSEFSSON EC.  BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death and Disease 2015 April 16;6, e1721; doi:10.1038/cddis.2015.97 PMID: 25880088